Temporal Protein Profiles

Use this form to calculate the temporal profiles of all proteins, protein complexes and cleavage products that are part of the model of apoptosome dependent apoptosis. Additionally, a profile for substrate cleavage by effector caspases will be calculated. Either input the desired initial protein concentrations [µM] and kinetic parameters [min] manually or select values for specific cell systems in the left frame.

Time frame to be simulated following cyt-c release:
[min]
Default Concentrations
Kinetic Parameters
Initial Procaspase-3:
[µM]
Initial Procaspase-9:
[µM]
Initial XIAP:
[µM]
Mitochondrial SMAC concentration:
[µM]
Initial APAF1:
[µM]

Cyt-c induced Apotosome formation kinetic (half-max. time):
[min]
SMAC release kinetic (half-max. time):
[min]


Caspase-3 knock out (0 = no, 1 = yes)


 

When choosing “Caspase-3 knock-out”, Caspase-3 and Caspase-3 dependent feed back loops are eliminated from the model, and effector caspase activity is adjusted to values for Caspase-7  
 


(Calculation may take a while, please wait for results)